Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction
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چکیده
منابع مشابه
The Interaction between Dietary Fiber and the Mediterranean Dietary Pattern Score with FTO Gene Polymorphisms in Relation to Obesity Phenotypes
Introduction: Although variants in the FTO gene have been found to be associated with susceptibility to obesity, however, recent studies suggest that dietary intakes may modify the association. This study aimed to investigate the interaction of the Mediterranean dietary pattern (MD) and fiber intake with FTO gene polymorphisms in relation to obesity phenotypes. Materials and Methods: Participan...
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BACKGROUND Emerging data suggest a role for the vitamin D receptor (VDR) in lipogenesis and adipocyte differentiation. OBJECTIVE Our objective was to evaluate the association of VDR gene variants and adiposity phenotypes in an epidemiologic study. DESIGN In a sample of 1773 healthy female adults recruited from western New York, we tested for the association of 14 VDR single nucleotide polym...
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The human genome hosts several active families of transposable elements (TEs), including the Alu, LINE-1, and SVA retrotransposons that are mobilized via reverse transcription of RNA intermediates. We evaluated how insertion polymorphisms generated by human retrotransposon activity may be related to common health and disease phenotypes that have been previously interrogated through genome-wide ...
متن کاملGlucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interaction.
The hypothalamic-pituitary-adrenal (HPA)-axis regulates the response to stressful events and is expected to be involved in the pathogenesis of depression. The glucocorticoid receptor (GR) regulates the activity of the HPA-axis. Both GR gene polymorphisms and childhood adversity are known to be associated with increased risk for depression. In the Longitudinal Aging Study Amsterdam, a large popu...
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BACKGROUND The gene encoding acyloxyacyl hydroxylase (AOAH), an enzyme that hydrolyzes secondary fatty acyl chains of LPS, is localized on chromosome 7p14-p12, where evidence for linkage to total IgE (tIgE) concentrations and asthma has been previously reported. OBJECTIVE We hypothesized that variants in AOAH are associated with asthma and related phenotypes. Because both AOAH and soluble CD1...
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ژورنال
عنوان ژورنال: BMC Medical Genetics
سال: 2017
ISSN: 1471-2350
DOI: 10.1186/s12881-017-0374-y